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Buparvaquone resistance appears to be associated with parasite mutations in the Q o quinone-binding site of mitochondrial cytochrome b. [3] Its mode of action is thus likely to be similar to that of the antimalarial drug atovaquone, a similar 2-hydroxy-1,4-naphthoquinone that binds to the Q o site of cytochrome b thus inhibiting Coenzyme Q – cytochrome c reductase.
Location of the MT-CYB gene in the human mitochondrial genome (coral box).. Cytochrome b is a protein that in humans is encoded by the MT-CYB gene. [5] Its gene product is a subunit of the respiratory chain protein ubiquinol–cytochrome c reductase (UQCR, complex III or cytochrome bc 1 complex), which consists of the products of one mitochondrially encoded gene, MT-CYB (mitochondrial ...
Cytochrome b is a protein found in the membranes of aerobic cells. In eukaryotic mitochondria (inner membrane) and in aerobic prokaryotes , cytochrome b is a component of respiratory chain complex III ( EC 1.10.2.2 ) — also known as the bc1 complex or ubiquinol-cytochrome c reductase.
Encounter between a solitary wild dolphin and human children in 1967. Educational anthropologist Dr. Betsy Smith of Florida International University is usually credited with starting the first line of research into dolphin-assisted therapy in 1971, building on earlier research by American neuroscientist Dr. John Lilly on interspecies communication between dolphins and humans in the 1950s. [11]
Complex IV contains a cytochrome a/a3-domain that transfers electrons and catalyzes the reaction of oxygen to water. Photosystem II, the first protein complex in the light-dependent reactions of oxygenic photosynthesis, contains a cytochrome b subunit. Cyclooxygenase 2, an enzyme involved in inflammation, is a cytochrome b protein.
When atovaquone is used as a sole agent, a high natural frequency of cytochrome b mutants leads to a high failure rate. This is potentially due to the high lipophilicity and slow uptake of atovaquone, which results in a relatively prolonged period of parasite exposure at ineffective concentrations. [ 8 ]
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13058 Ensembl ENSG00000165168 ENSMUSG00000015340 UniProt P04839 Q61093 RefSeq (mRNA) NM_000397 NM_007807 RefSeq (protein) NP_000388 NP_031833 Location (UCSC) Chr X: 37.78 – 37.81 Mb Chr X: 9.3 – 9.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is ...