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Nucleic acid amplification tests (NAATs) tests find the genetic material (DNA) of Chlamydia bacteria. These tests are the most sensitive tests available, meaning they are very accurate and are unlikely to have false-negative test results. A polymerase chain reaction (PCR) test is an example of a nucleic acid amplification test. This test can ...
If left untreated, chlamydia in men can spread to the testicles causing epididymitis, which in rare cases can lead to sterility if not treated. [15] Chlamydia is also a potential cause of prostatic inflammation in men, although the exact relevance in prostatitis is difficult to ascertain due to possible contamination from urethritis.
The small genome of M. genitalium made it the organism of choice in The Minimal Genome Project, a study to find the smallest set of genetic material necessary to sustain life. [30] There is limited divergence among clinical strains of M. genitalium. All strains retain the small genome size. [31]
In some instances a disease can be carried with no symptoms, which leaves a greater risk of passing the disease on to others. Depending on the disease, some untreated STIs can lead to infertility, chronic pain or death. [12] The presence of an STI in prepubescent children may indicate sexual abuse. [13]
DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. [1] The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage. [2] DNA damage and mutation have ...
Genotoxic substances induce damage to the genetic material in the cells through interactions with the DNA sequence and structure. For example, the transition metal chromium interacts with DNA in its high-valent oxidation state, incurring DNA lesions which lead to carcinogenesis. The metastable oxidation state Cr(V) is achieved through reductive ...
Traditional DNA analysis was largely limited to samples that contained genetic material from a couple of people, said Monica Ghannam, a forensic scientist who testified in the Caneiro hearing ...
The genes within the gonococcal genetic island encode for the infamous type IV secretion system (T4SS), which is responsible for DNA secretion and is essential for biofilm formation. [ 66 ] [ 68 ] In 2011, researchers at Northwestern University found evidence of a human DNA fragment in a N. gonorrhoeae genome, the first example of horizontal ...