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The bafilomycins are a family of macrolide antibiotics produced from a variety of Streptomycetes. Their chemical structure is defined by a 16-membered lactone ring scaffold. [2] Bafilomycins exhibit a wide range of biological activity, including anti-tumor, [3] anti-parasitic, [4] [5] immunosuppressant [6] and anti-fungal [7] activity.
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