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Classic DNA inhibitors such as the quinolones act upon DNA gyrase as a topoisomerase inhibitor. [2] Another group of DNA inhibitors, including nitrofurantoin and metronidazole, act upon anaerobic bacteria. [3] These act by generating metabolites that are incorporated into DNA strands, which then are more prone to breakage. [4] These drugs are ...
Dihydropteroate synthase inhibitors are drugs that inhibit the action of dihydropteroate synthase. They include sulfonamides, dapsone, and para-aminosalicylic acid. [1] Tetrahydrofolate synthesis pathway. In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase, DHPS.
PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). [1] PCR inhibition is the most common cause of amplification failure when sufficient copies of DNA are present. [2] PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.
1719 13361 Ensembl ENSG00000228716 ENSMUSG00000021707 UniProt P00374 P00375 RefSeq (mRNA) NM_000791 NM_001290354 NM_001290357 NM_010049 RefSeq (protein) NP_000782 NP_001277283 NP_001277286 NP_034179 Location (UCSC) Chr 5: 80.63 – 80.65 Mb Chr 13: 92.49 – 92.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic ...
A hypomethylating agent (or demethylating agent [1]) is a drug that inhibits DNA methylation: the modification of DNA nucleotides by addition of a methyl group.Because DNA methylation affects cellular function through successive generations of cells without changing the underlying DNA sequence, treatment with a hypomethylating agent is considered a type of epigenetic therapy.
LexA polypeptides contains a two domains: a DNA-binding domain and a dimerization domain. [3] The dimerization domain binds to other LexA polypeptides to form dumbbell shaped dimers. The DNA-binding domain is a variant form of the helix-turn-helix DNA binding motif, [4] and is usually located at the N-terminus of the protein. [1]
The cytoplasmic membrane is a frequent target, but peptides may also interfere with DNA and protein synthesis, protein folding, and cell wall synthesis. [10] The initial contact between the peptide and the target organism is electrostatic, as most bacterial surfaces are anionic, or hydrophobic, such as in the antimicrobial peptide Piscidin.
A protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. [ 1 ] A ribosome is a biological machine that utilizes protein dynamics on nanoscales to translate RNA into proteins