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The lipid hypothesis (also known as the cholesterol hypothesis) is a medical theory postulating a link between blood cholesterol levels and the occurrence of cardiovascular disease. A summary from 1976 described it as: "measures used to lower the plasma lipids in patients with hyperlipidemia will lead to reductions in new events of coronary ...
Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biologyand disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation.
George V. Mann was an American medical researcher, physician, academic, and author known for his research on cholesterol's impact on cardiovascular health.He served as an assistant professor at Harvard University early in his career and as a professor and researcher of medicine and biochemistry at Vanderbilt University until his retirement.
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries. This is a chronic inflammatory disease involving many different cell types and is driven by elevated levels of cholesterol in the blood. [ 9 ]
Hyperlipidemia predisposes a person to atherosclerosis. Atherosclerosis is the accumulation of lipids, cholesterol, calcium, fibrous plaques within the walls of arteries. [61] This accumulation narrows the blood vessel and reduces blood flow and oxygen to muscles of the heart.
Progression of atherosclerosis. A fatty streak is the first grossly visible (visible to the naked eye) lesion in the development of atherosclerosis.It appears as an irregular yellow-white discoloration on the luminal surface of an artery.
Atherosclerosis is a hardening of an artery specifically due to an atheromatous plaque. The term atherogenic is used for substances or processes that cause atherosclerosis. Micrograph showing hyaline arteriolosclerosis in the kidney. PAS stain.
Breslow's research has focused on the genetic factors that govern an individual's predisposition to develop atherosclerosis. [4] He started to work on the genetics of cholesterol handling in the late 1970s, [5] and in the early 1980s, with Vassilis Zannis, he was one of the earliest to dissect the different variants of human apolipoprotein E (ApoE), a component of very low-density lipoprotein. [6]