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Charlotte's Web is a brand of high-cannabidiol (CBD), low-tetrahydrocannabinol (THC) products derived from industrial hemp and marketed as dietary supplements and cosmetics under federal law of the United States. [1] [2] [3] It is produced by Charlotte's Web, Inc. in Colorado.
Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. [17] Medically, it is an anticonvulsant used to treat multiple forms of epilepsy . [ 4 ]
Sisters of the Valley is a small business that sells cannabidiol tinctures, cannabidiol infused oil, and cannabidiol salves, for oral and topical use, made with ethanol and coconut oil, via their website and the craft e-commerce website Etsy. It is based in Merced, California, and its proprietors follow a monastic motif.
Cannabidiol has little affinity for CB 1 and CB 2 receptors but acts as an indirect antagonist of cannabinoid agonists. [25] It was found to be an antagonist at the putative new cannabinoid receptor, GPR55, a GPCR expressed in the caudate nucleus and putamen. [26] Cannabidiol has also been shown to act as a 5-HT 1A receptor agonist. [27]
Western Australia was the first state in Australia to prohibit the sale of certain synthetic cannabinoids. [ 193 ] [ 194 ] On June 18, 2013, an interim ban made a large list of product brands and synthetic substances illegal to sell anywhere in Australia. [ 195 ]
It is related to cannabidiol, with the pentyl side chain shortened to a methyl group. Cannabidiorcol has low affinity for cannabinoid receptors and is mainly active as an agonist of the TRPV2 cation channel, through which it produces antiinflammatory effects, [ 1 ] but can also promote tumorigenesis at high concentrations.
Cannabidiol diacetate (CBD-di-O-Acetate, CBD-DO) is a semi-synthetic derivative of cannabidiol derived by acetylation of the OH groups, [1] which presumably acts as a prodrug for CBD. It has been found as a component of grey-market cannabis products such as e-cigarette liquids and edible gummy lollies.
Cannabis Station, a medical cannabis dispensary in Denver, Colorado Cannabis flower stored in jars at a dispensary in Colorado. Cannabis dispensaries in the United States or marijuana dispensaries are a type of cannabis retail outlet, local government-regulated physical location, typically inside a retail storefront or office building, in which a person can purchase cannabis and cannabis ...