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The design of experiments (DOE), [1] also known as experiment design or experimental design, is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation.
Design of Experiments: A systematic, rigorous approach to engineering problem-solving that applies principles and techniques at the data collection stage so as to ensure the generation of valid, defensible, and supportable engineering conclusions [1] Design Point: A single combination of settings for the independent variables of an experiment.
Analytical chemistry; List of materials analysis methods This page was last edited on 14 November 2023, at 15:12 (UTC). Text is available under the Creative Commons ...
Protein folding problem: Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will adopt a given structure under certain environmental conditions?
In some cases, simply doing a reverse titration of changing the samples between the injection syringe and sample cell can solve the issue, depending on the binding mechanism. However, the process of introducing a ligand to a macromolecule is distinct from the process of adding a macromolecule to a ligand. [ 15 ]
In the mathematical theory on optimal experiments, an optimal design can be a probability measure that is supported on an infinite set of observation-locations. Such optimal probability-measure designs solve a mathematical problem that neglected to specify the cost of observations and experimental runs.
Potentiometry passively measures the potential of a solution between two electrodes, affecting the solution very little in the process. One electrode is called the reference electrode and has a constant potential, while the other one is an indicator electrode whose potential changes with the sample's composition.
Note that this is not limited to liquid samples. In atomic absorption spectroscopy, for example, standard additions are often used with solid as the sample. [6] In atomic emission spectroscopy, background signal cannot be resolved by standard addition. Thus, background signal must be subtracted from the unknown and standard intensities prior to ...