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Factor VII deficiency is a bleeding disorder characterized by a lack in the production of Factor VII (FVII) (proconvertin), a protein that causes blood to clot in the coagulation cascade. After a trauma factor VII initiates the process of coagulation in conjunction with tissue factor (TF/factor III) in the extrinsic pathway.
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone .
There are a variety of rare diseases that resemble GH deficiency, including the childhood growth failure, facial appearance, delayed bone age, and low insulin-like growth factor-1 (IGF-1) levels. However, GH testing elicits normal or high levels of GH in the blood, demonstrating that the problem is not due to a deficiency of GH but rather to a ...
2155 14068 Ensembl ENSG00000057593 ENSMUSG00000031443 UniProt P08709 P70375 RefSeq (mRNA) NM_000131 NM_001267554 NM_019616 NM_010172 RefSeq (protein) NP_000122 NP_001254483 NP_062562 NP_034302 Location (UCSC) Chr 13: 113.11 – 113.12 Mb Chr 8: 13.08 – 13.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is a ...
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene. [ 5 ] GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos .
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development , cell growth, morphogenesis , tissue repair, tumor growth and invasion.
Insulin-like growth factor 2 (IGF-2, at times IGF-II) is thought to be a primary growth factor required for early development while IGF-1 expression is required for achieving maximal growth. Gene knockout studies in mice have confirmed this, though other animals are likely to regulate the expression of these genes in distinct ways.
[5] [6] [7] GDF5 is expressed in the developing central nervous system, with roles in the development of joints and the skeleton, and increasing the survival of neurones that respond to a neurotransmitter called dopamine. [8] [9] [10] GDF6 interacts with bone morphogenetic proteins to regulate ectoderm patterning, and controls eye development ...