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Lipidomics is a research field that studies the pathways and networks of cellular lipids in biological systems (i.e., lipidomes) on a large scale. It involves the identification and quantification of the thousands of cellular lipid molecular species and their interactions with other lipids, proteins, and other moieties in vivo.
Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems. [ 1 ] [ 2 ] [ 3 ] The word " lipidome " is used to describe the complete lipid profile within a cell, tissue, organism, or ecosystem and is a subset of the " metabolome " which also includes other major classes of biological molecules (such as ...
LIPID MAPS (Lipid Metabolites and Pathways Strategy) is a web portal designed to be a gateway to Lipidomics resources. The resource has spearheaded a classification of biological lipids, dividing them into eight general categories. [1] LIPID MAPS provides standardised methodologies for mass spectrometry analysis of lipids, e.g. [2] [3] [4]
The SEE-FIM protocol is a pathology dissection protocol for Sectioning and Extensively Examining the Fimbria (SEE-FIM). This protocol is intended to provide for the optimal microscopic examination of the distal fallopian tube (fimbria) to identify either cancerous or precancerous conditions in this organ.
Diagram illustrating genomics. Omics is the collective characterization and quantification of entire sets of biological molecules and the investigation of how they translate into the structure, function, and dynamics of an organism or group of organisms.
A 2024 systematic review of the literature found that chemoradiation with 5-FU and mitomycin C, as used in the Nigro Protocol, improves outcomes like colostomy-free survival in anal cancer patients compared to alternatives like cisplatin. However, it can lead to more severe side effects, especially blood-related toxicity. [7]
This separation step is not mandatory and is often omitted in NMR and "shotgun" based approaches such as shotgun lipidomics. Gas chromatography (GC), especially when interfaced with mass spectrometry , is a widely used separation technique for metabolomic analysis.
Johanna Budwig (1908 – 2003) was a German biochemist, alternative cancer treatment advocate and writer. [1] Budwig was a pharmacist and held doctorate degrees in physics and chemistry. [2] Based on her research on fatty acids she developed a lacto-vegetarian diet that she believed was useful in the treatment of cancer. There is no clinical ...