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The aminopenicillins are a group of antibiotics in the penicillin family that are structural analogs of ampicillin (which is the 2-amino derivative of benzylpenicillin, hence the name). [1] Like other penicillins and beta-lactam antibiotics , they contain a beta-lactam ring that is crucial to its antibacterial activity.
Ciclacillin or cyclacillin (), trade names Cyclapen, Cyclapen-W, Vastcillin, and others, is an aminopenicillin antibiotic.Its spectrum of activity is similar to that of ampicillin, although it is less susceptible to beta-lactamases than ampicillin and has much higher bioavailability. [1]
Ampicillin is an antibiotic belonging to the aminopenicillin class of the penicillin family. The drug is used to prevent and treat several bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis. [7]
Some sources identify them with antipseudomonal penicillins, [2] others consider these types to be distinct. [3] This group includes the carboxypenicillins and the ureidopenicillins . Aminopenicillins , in contrast, do not have activity against Pseudomonas species, as their positively charged amino group does not hinder degradation by ...
6-APA ((+)-6-aminopenicillanic acid) is a chemical compound used as an intermediate in the synthesis of β–lactam antibiotics.The major commercial source of 6-APA is still natural penicillin G.
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Hetacillin is a beta-lactam antibiotic that is part of the aminopenicillin family. It is a prodrug and has no antibacterial activity itself, [ 1 ] but quickly splits off acetone in the human body to form ampicillin , [ 2 ] which is active against a variety of bacteria.
Mecillinam or amdinocillin is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2), [2] and is only considered to be active against Gram-negative bacteria.