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Ciprofloxacin is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Its empirical formula is C 17 H 18 FN 3 O 3 and its molecular weight is 331.4 g/mol. It is a faintly yellowish to light yellow crystalline substance. [68] Ciprofloxacin hydrochloride is the monohydrochloride monohydrate salt of ciprofloxacin ...
Ciprofloxacin, a fluoroquinolone antibiotic, has shown in vitro activity against many Gram-positive and Gram-negative bacteria including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Pseudomonas aeruginosa.
Otitis externa may be acute (lasting less than six weeks) or chronic (lasting more than three months). [2] Acute cases are typically due to bacterial infection, and chronic cases are often due to allergies and autoimmune disorders. [2] [3] The most common cause of otitis externa is bacterial.
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production.
Otitis externa, also known as swimmer's ear, is an inflammation (infectious or non-infectious) of the external auditory canal. [14] Risk factors include retained water in the outer ear, particularly due to swimming, humidity, trauma or external devices, dermatologic conditions, or scratching the ear canal that may lead to bacterial growth.
Strep throat does not usually cause a runny nose, voice changes, or cough. [citation needed] Pain and pressure of the ear caused by a middle-ear infection (otitis media) and the reddening of the eye caused by viral conjunctivitis [10] are often associated with URTIs.
Clinically, patients experience aural fullness, intra-meatal itching, and malodorous otorrhea all at the same time. Although granular myringitis does not typically result in a hearing loss, it can cause complications like inflammatory infiltration of the deep canal, canal atresia or stenosis, and post-inflammatory medial canal fibrosis.
Finafloxacin is used to treat a type of ear infection called acute otitis externa caused by Pseudomonas aeruginosa and Staphylococcus aureus bacteria. [3] In the clinical trial that led to the drug's approval, finafloxacin shortened the time to cessation of ear pain from an average of 6.8 days in patients taking a placebo to 3.5 days.