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Alka-Seltzer is an effervescent antacid and pain reliever owned by Bayer since 1978. First marketed by the Dr. Miles Medicine Company of Elkhart, Indiana, United States, Alka-Seltzer contains three active ingredients: aspirin (acetylsalicylic acid or ASA), sodium bicarbonate, and anhydrous citric acid. [1]
Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate [9]), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO 3. It is a salt composed of a sodium cation (Na +) and a bicarbonate anion (HCO 3 −). Sodium bicarbonate is a white solid that is crystalline but often appears as a
It originally contained sodium bromide and acetanilide, both toxic substances which were eventually removed. Its current formulation contains the pain reliever aspirin and two reactive chemicals – sodium bicarbonate and citric acid – which creates effervescence when mixed with water. Sodium bicarbonate is an antacid.
Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. [10] Aspirin is not recommended in the last part of pregnancy. [10] It is not generally recommended in children with infections because of the risk of Reye syndrome. [10] High doses may result in ringing in the ears. [10]
Sodium bicarbonate is given in a significant aspirin overdose (salicylate level greater than 35 mg/dL 6 hours after ingestion) regardless of the serum pH, as it enhances elimination of aspirin in the urine. It is given until a urine pH between 7.5 and 8.0 is achieved.
Eno was first marketed by James Crossley Eno (1827–1915). [4] Legend has it that his idea for the product arose while he was working at the pharmacy of an infirmary in Newcastle, Britain, with Dennis Embleton; Embleton often prescribed an effervescent drink made by mixing sodium bicarbonate and citric acid in water, and Eno adopted this beverage. [5]
A recent survey found that while the number of adults using aspirin to prevent heart disease has decreased, about one-third of adults ages 60 and older without heart disease were still taking ...
Therefore, in cases of aspirin (weak acid) toxicity, injecting intravenous sodium bicarbonate could increase urine pH, thereby increasing the excretion of aspirin through urine. [27] A similar approach can be used in other weakly acidic drug toxicity.