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The animal extracellular matrix includes the interstitial matrix and the basement membrane. [7] Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. [ 8 ]
Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. [1] It is an irreversible, covalent cross-link product that has been found to make intermolecular and intramolecular cross-links in the collagen of the extracellular matrix (ECM) and crystallin of the eyes. [2]
A matricellular protein is a dynamically expressed non-structural protein that is present in the extracellular matrix (ECM). [1] [2] Rather than serving as stable structural elements in the ECM, these proteins are rapidly turned over and have regulatory roles. They characteristically contain binding sites for ECM structural proteins and cell ...
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Matrigel is the trade name for the solubilized basement membrane matrix secreted by Engelbreth-Holm-Swarm (EHS) mouse sarcoma cells produced by Corning Life Sciences. . Matrigel resembles the laminin/collagen IV-rich basement membrane extracellular environment found in many tissues and is used by cell biologists as a substrate (basement membrane matrix) for culturi
Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. [5] In humans, the MMP-8 protein is encoded by the MMP8 gene. [6] [7] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [5]
CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. [1] [2] Due to their dynamic role within the ECM they are considered matricellular proteins. [3] [4] [5]
Within each of the alpha and beta subunits there is a large extracellular domain, a transmembrane domain and a short cytoplasmic domain. [13] The extracellular domain is where the ligand binds through the use of divalent cations. The integrins contain multiple divalent cation binding sites in the extracellular domain [14]). The integrin cation ...