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Endometrial hyperplasia is a condition of excessive proliferation of the cells of the endometrium, or inner lining of the uterus.. Most cases of endometrial hyperplasia result from high levels of estrogens, combined with insufficient levels of the progesterone-like hormones which ordinarily counteract estrogen's proliferative effects on this tissue.
Uterine hyperplasia, or enlarged uterus, is a medical symptom in which the volume and size of the uterus in a female is abnormally high. It can be a symptom of medical conditions such as adenomyosis , uterine fibroids , ovarian cysts , and endometrial cancer .
Megestrol acetate was reported to be effective in the treatment of endometrial hyperplasia in the mid-1960s. [6] It first started to be studied as a treatment for endometrial cancer in 1967, with findings published in 1973. [6] [156] [157] Megestrol acetate was reportedly introduced for the treatment of endometrial cancer in the United States ...
Mutations in the KRAS gene can cause endometrial hyperplasia and therefore Type I endometrial cancer. [37] Endometrial hyperplasia typically occurs after the age of 40. [9] Endometrial glandular dysplasia occurs with an overexpression of p53, and develops into a serous carcinoma. [15]
Metropathia haemorrhagica, also known as metropathia haemorrhagica cystica, is a menstrual disorder which is defined as a specialized type of anovulatory dysfunctional uterine bleeding associated with endometrial hyperplasia and intermenstrual bleeding.
Hyperplasia of the breast – "Hyperplastic" lesions of the breast include usual ductal hyperplasia, a focal expansion of the number of cells in a terminal breast duct, and atypical ductal hyperplasia, in which a more abnormal pattern of growth is seen, and which is associated with an increased risk of developing breast cancer.
The endometrial hyperplasia that leads to endometrial cancer with estrogen therapy can be prevented by concomitant administration of progestogen. [60] The extensive use of high-dose estrogens for birth control in the 1970s is thought to have resulted in a significant increase in the incidence of type 1 endometrial cancer. [61]
There are a number of indications for obtaining an endometrial biopsy from a non-pregnant woman: [citation needed]. Women with chronic anovulation such as the polycystic ovary syndrome are at increased risk for endometrial problems and an endometrial biopsy may be useful to assess their lining specifically to rule out endometrial hyperplasia or cancer.