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Trimethobenzamide synthesis: Hoffmann La Roche, U.S. patent 2,879,293 (1959). Alkylation of the sodium salt of p -hydroxybenzaldehyde (1) with 2-dimethylaminoethyl chloride affords the ether (2). Reductive amination of the aldehyde in the presence of ammonia gives diamine (3).
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3,4,5-Trimethoxybenzaldehyde can be used as an intermediate in the synthesis of some pharmaceutical drugs including trimethoprim, [1] [2] cintriamide, roletamide, trimethoquinol (aka tretoquinol), and trimazosin as well as some psychedelic phenethylamines.
2 Synthesis. 3 Derivatives. 4 References. Toggle the table of contents. ... Trimethobenzamide; Trimetozine; Tritiozine (ala trimetozine but thioamide). Trocimine ...
Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α 1-adrenergic, H 1, and mACh receptor antagonism, [9] it additionally produces potent blockade of several serotonin receptors, including 5-HT 2A, 5-HT 2C, and 5-HT 7.
DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride) is an organic triazine derivative commonly used for activation of carboxylic acids, particularly for amide synthesis. Amide coupling is one of the most common reactions in organic chemistry and DMTMM is one reagent used for that reaction.
There various synthetic methods for the synthesis of formazans. [8] [9] The reaction of diazonium compounds with aldehyde hydrazones is one of the most common procedures to produce formazans. Hydrazones, which are electron-rich compounds, react with diazonium salts either at a nitrogen or a carbon atom to produce formazans.
The synthesis consists of three steps. In the first step, 2-iodobenzoic acid is oxidized by sodium periodate and cyclized to 1-hydroxy-1,2-benziodoxol-3(1 H )-one. The target compound can then be obtained by acylation with acetic anhydride and subsequent substitution reaction with trifluoromethyltrimethylsilane .