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The discovery of testosterone in 1935 led to the development of testosterone replacement therapy (TRT), which has since become a cornerstone treatment for male hypogonadism. Additionally, hormone replacement therapy (HRT) for women has advanced, providing solutions for conditions such as menopause-related hypogonadism. [ 9 ]
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Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often testosterone, are supplemented or replaced. It typically involves the administration of testosterone through injections, skin creams, patches, gels, pills, or subcutaneous pellets.
Testosterone supplementation is also known to reduce the threshold for aggressive behavior in men. [9] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).
Therefore, low-dose TU appears to be a safe and cost-effective protocol for treating elderly male osteoporosis. [56] However, further clinical trials with larger sample sizes, multiple centers, and long-term follow-ups are required to determine the efficacy and safety of low-dose testosterone undecanoate treatment in elderly male osteoporosis ...
Testosterone enanthate is used primarily in androgen replacement therapy. [4] [15] It is the most widely used form of testosterone in androgen replacement therapy. [4]The medication is specifically approved, in the United States, for the treatment of hypogonadism in men, delayed puberty in boys, and breast cancer in women. [16]
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