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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
Chronic overtraining—though uncommon for most exercisers—can cause consistently elevated cortisol levels, which might result in symptoms like: Fatigue or feeling run down Trouble sleeping or ...
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
[3] [5] Twin studies show its pattern is largely genetically determined since there is a heritability of 0.40 for the mean cortisol increase after awakening and 0.48 for the area under the cortisol rise curve. [6] Normally, the highest cortisol secretion happens in the second half of the night with peak cortisol production occurring in the ...
About 70% of people with Cushing syndrome are women or people assigned female at birth, according to the Cleveland Clinic. People between 25 and 50 are most likely to be affected by the condition.
Physically, it can cause fatigue, trouble sleeping and appetite changes. When stress becomes chronic and cortisol levels ... Mentally, it can lead to anxiety and depression, burnout at work, and ...
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