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The cell bodies of sensory neurons known as first-order neurons are located in the dorsal root ganglia. [2] The axons of dorsal root ganglion neurons are known as afferents. In the peripheral nervous system, afferents refer to the axons that relay sensory information into the central nervous system (i.e. the brain and the spinal cord).
The first-order neuron is a pseudounipolar neuron (shown left), with a single axon originating from the cell body then splitting into two branches. The body is situated in the dorsal root ganglion, with one axon traveling peripherally to tissue, and one traveling into the dorsal column. On the right is a bipolar neuron.
The root emerges from the posterior part of the spinal cord and travels to the dorsal root ganglion. The dorsal root ganglia contain the pseudo-unipolar cell bodies of the nerve fibres which travel from the ganglia through the root into the spinal cord. The lateral division of the dorsal root contains lightly myelinated and unmyelinated fibres ...
A dorsal root ganglion (DRG) from a chicken embryo (around stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Note the axons growing out of the ganglion. A ganglion (pl.: ganglia) is a group of neuron cell bodies in the peripheral nervous system.
General somatic afferents conduct impulses of pain, touch and temperature from the surface of the body through the dorsal roots to the spinal cord, and impulses of muscle sense, tendon sense and joint sense from the deeper structures.
For example, in a rat model, large bundles of greater than 20 axons are found exiting the L5 dorsal root ganglion, while smaller bundles of average 3 axons are found in distal nerve segments. [3] Multiple neurons contribute axons to the Remak bundle with an average ratio of about 2 axons contributed per bundle. [3]
Sectional organization of spinal cord. The spinal cord is the main pathway for information connecting the brain and peripheral nervous system. [3] [4] Much shorter than its protecting spinal column, the human spinal cord originates in the brainstem, passes through the foramen magnum, and continues through to the conus medullaris near the second lumbar vertebra before terminating in a fibrous ...
Between the brain and the body, the spinal cord is the most crucial component. From the foramen magnum, where it joins the medulla, the spinal cord reaches the first or second lumbar vertebrae. It is an essential connection between the body and the brain as well as between the two.