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The classic description of rheumatoid nodulosis in adults is that it is a variation of rheumatoid arthritis (RA) that appears as a proliferation of subcutaneous nodules, frequently on the hands and feet, linked to palindromic rheumatism without loss of joint function and with minimal to no systemic symptoms. [2]
Rheumatoid nodulosis is characterized by multiple subcutaneous nodules presenting with rheumatoid factors but an absence of joint complaints. The nodules are typically small and concentrated on the extensor sites of the hands and feet, sometimes accompanied by bone erosions.
[20] [21] [22] Rheumatoid nodulosis, which may occur in joint areas, can vary in its effect on hand function. [23] Milder cases often do not disturb daily function, whereas severe ones may induce loss-of-function. [23] Besides this, gouty arthritis can be associated with tophi deposits in the joints of the hand. [22] Gout can induce pain and ...
Caplan syndrome presents with cough and shortness of breath in conjunction with features of rheumatoid arthritis, such as painful joints and morning stiffness. Examination should reveal tender, swollen metacarpophalangeal joints and rheumatoid nodules; auscultation of the chest may reveal diffuse crackles that do not disappear on coughing or taking a deep breath.
Rheumatoid arthritis - autoimmune disease with an unclear cause that manifests as symmetric, erosive synovitis and, occasionally, extraarticular involvement. [19] Systemic lupus erythematosus - chronic, complex autoimmune inflammatory disorder that can affect every organ in the body. [20] Scleroderma - diverse collection of autoimmune fibrosing ...
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