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Rheumatoid nodulosis is characterized by multiple subcutaneous nodules presenting with rheumatoid factors but an absence of joint complaints. The nodules are typically small and concentrated on the extensor sites of the hands and feet, sometimes accompanied by bone erosions.
Rheumatoid nodulosis is a cutaneous condition associated with rheumatoid arthritis, characterized by the appearance of multiple nodules, most often on the hands. [ 1 ] Signs and symptoms
Rheumatoid vasculitis may affect almost any organ in the body. The skin and peripheral nerves are the most frequently affected areas. Although major organ system involvement of the kidney, bowel, or heart is much less common, it can result in serious morbidity and mortality, such as renal failure, bowel ischemia, and myocardial infarction. [3]
Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic (), nodular lesions, which commonly appear on the trunk, arms and legs. [1]
Methotrexate-induced papular eruption; Mikulicz disease; Mixed connective tissue disease; Morphea; Morphea en coup de sabre; Morphea plana atrophica; Moulin atrophoderma linearis; Mouth and genital ulcers with inflamed cartilage syndrome
Rheumatoid nodulosis (accelerated rheumatoid nodulosis) Rheumatoid vasculitis; Rowell's syndrome; Scleredema adultorum (Bushke disease, scleredema diabeticorum, scleredema adultorum of Buschke, scleredema of Buschke) Silicosis; Sjögren's syndrome (Mikulicz disease, Sicca syndrome) Subacute cutaneous lupus erythematosus; Systemic lupus ...
Caplan syndrome presents with cough and shortness of breath in conjunction with features of rheumatoid arthritis, such as painful joints and morning stiffness. Examination should reveal tender, swollen metacarpophalangeal joints and rheumatoid nodules; auscultation of the chest may reveal diffuse crackles that do not disappear on coughing or taking a deep breath.
Glucarpidase is an enzyme that inactivates methotrexate rapidly after injection. Because this agent reduces systemic levels of methotrexate and could therefore interfere with efficacy, it is not recommended for use in patients with normal or only slightly impaired kidney function or in whom serum levels are normal.