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Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. [3] Pyoderma gangrenosum is not infectious. [3] Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. [2] The disease was identified in 1930.
Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease. It presents as poorly healing ulcers with undermined edges. Pathergy is an important feature (this term refers to the tendency of ulcers to arise at points of injury).
Diabetes mellitus type 1: Pancreas: Anti-insulin, anti-IA-2, anti-GAD, anti-ZnT8 antibodies Confirmed 1.6 per 1,000 [78] Endometriosis: Endometrium: Anti-endometrial antibodies Probable 6-10% of women of reproductive age [79] Graves' disease: Thyroid gland: TSI, TPO, TG antibodies Confirmed 1.2% of the population [80] Hashimoto's thyroiditis ...
Comorbid ailments that may contribute to the formation of chronic wounds include vasculitis (an inflammation of blood vessels), immune suppression, pyoderma gangrenosum, and diseases that cause ischemia. [2] Immune suppression can be caused by illnesses or medical drugs used over a long period, like steroids. [2]
The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy. The pathergy reaction is a unique feature of Behçet's disease and, according to the International Study Group for Behcet's Disease, is among the major criteria required for the diagnosis.
Rare causes of skin ulcers include pyoderma gangraenosum, lesions caused by Crohn's disease or ulcerative colitis, granulomatosis with polyangiitis, morbus Behçet and infections that are usually seen in those who are immunocompromised, for example ecthyma gangraenosum.
Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters, which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. " Ecthyma " means a pus-forming infection of the skin with an ulcer, "gangrenosum" refers to the accompanying gangrene or necrosis.
Gangrene toes in a diabetic. Gangrene is a type of tissue death caused by a lack of blood supply. [4] The feet and hands are most commonly affected. [1] If the gangrene is caused by an infectious agent, it may present with a fever or sepsis.
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