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In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
Statistical significance. In statistical hypothesis testing, [1][2] a result has statistical significance when a result at least as "extreme" would be very infrequent if the null hypothesis were true. [3] More precisely, a study's defined significance level, denoted by , is the probability of the study rejecting the null hypothesis, given that ...
Although this p-value objectified research outcome, using it as a rigid cut off point can have potentially serious consequences: (i) clinically important differences observed in studies might be statistically non-significant (a type II error, or false negative result) and therefore be unfairly ignored; this often is a result of having a small ...
Power (statistics) In frequentist statistics, power is a measure of the ability of an experimental design and hypothesis testing setup to detect a particular effect if it is truly present. In typical use, it is a function of the test used (including the desired level of statistical significance), the assumed distribution of the test (for ...
Medical statistics (also health statistics) deals with applications of statistics to medicine and the health sciences, including epidemiology, public health, forensic medicine, and clinical research. [1] Medical statistics has been a recognized branch of statistics in the United Kingdom for more than 40 years, but the term has not come into ...
Sample size determination. Sample size determination or estimation is the act of choosing the number of observations or replicates to include in a statistical sample. The sample size is an important feature of any empirical study in which the goal is to make inferences about a population from a sample. In practice, the sample size used in a ...
Analysis of clinical trials. Clinical trials are medical research studies conducted on human subjects. [1] The human subjects are assigned to one or more interventions, and the investigators evaluate the effects of those interventions. [1][2] The progress and results of clinical trials are analyzed statistically. [3][4]
[8] [30] Efficacy outcomes that are statistically significant have a higher chance of being fully published compared to those that are not statistically significant. Selective reporting of suspected or confirmed adverse treatment effects is an area for particular concern because of the potential for patient harm.