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Treatment is by excisional biopsy, wide local excision and possibly sentinel node biopsy. Localized melanoma, which has not spread beyond the skin, has a very good prognosis with low recurrence rates. Spread of disease to local lymph nodes or distant sites (typically brain, bone, skin and lung) marks a decidedly poor prognosis.
Lentigo maligna is a histopathological variant of melanoma in situ. [6] Lentigo maligna is sometimes classified as a very early melanoma, [7] and sometimes as a precursor to melanoma. [8] When malignant melanocytes from a lentigo maligna have invaded below the epidermis, the condition is termed lentigo maligna melanoma. [2]
Vemurafenib , sold under the brand name Zelboraf, is a medication used for the treatment of late-stage melanoma. [2] It is an inhibitor of the B-Raf enzyme and was developed by Plexxikon . [ 2 ]
Acral lentiginous melanoma (ALM) is a type of skin cancer. [6] It typically begins as a uniform brownish mark before becoming darker and wider with a blurred, irregular border. ALM is most frequently seen on the foot of a person with darker skin but can also be found in non-sun exposed areas such as the palms , soles , and under finger and ...
Skin cancer is the most commonly diagnosed form of cancer in humans. [11] [12] [13] There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. [1] The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC).
Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes. [1] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [1] [2] In women, melanomas most commonly occur on the legs; while in men, on the back. [2]
Nevoid melanoma. A nevoid melanoma is a malignant neoplastic lesion of the skin. It is a type of melanoma, the most dangerous form of skin cancer.Nevoid melanomas are clinically significant because they are difficult to distinguish from a benign nevus of the skin, which requires no treatment and is common on most individuals.
Amelanotic melanoma is a type of skin cancer in which the cells do not make any melanin. [1]: 696 [2] They can be pink, red, purple or of normal skin color, and are therefore difficult to diagnose correctly. They can occur anywhere on the body, just as a typical melanoma can.
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