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  2. Adenosine diphosphate receptor inhibitor - Wikipedia

    en.wikipedia.org/wiki/Adenosine_diphosphate...

    All proton pump inhibitors except for rabeprazole and pantoprazole are metabolized by the hepatic CYP450 enzyme and therefore, may interact with the metabolism of clopidogrel. Omeprazole is considered to have higher potential for drug-drug interaction than other protein pump inhibitors because it is a CYP2C19 inhibitor. [17]

  3. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    Compared to warfarin it has fewer interactions with other medications. [13] It is a direct factor Xa inhibitor. [9] In 2007, Pfizer and Bristol-Myers Squibb began the development of apixaban as an anticoagulant. [14] Apixaban was approved for medical use in the European Union in May 2011, and in the United States in December 2012.

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Direct factor Xa inhibitors can be considered as an alternative to warfarin, particularly if a person is on several other medications that interact with warfarin, or if attending medical appointments and laboratory monitoring becomes difficult. [8]

  5. Omeprazole - Wikipedia

    en.wikipedia.org/wiki/Omeprazole

    Important drug interactions are rare. [38] [39] However, the most significant major drug interaction concern is the decreased activation of clopidogrel when taken together with omeprazole. [40] Although still controversial, [41] this may increase the risk of stroke or heart attack in people taking clopidogrel to prevent these events.

  6. The 12 most shocking Oscar moments ever (from Will Smith to ...

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    The "Grease" actor launched a thousand memes when he introduced the "Frozen" star's performance of "Let It Go," unintelligibly pronouncing her name as "Adele Dazeem." 10. Chris Rock takes no ...

  7. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

  8. Bill Murray Makes Rare Comment About His Personal Life: 'I ...

    www.aol.com/bill-murray-makes-rare-personal...

    Bill Murray is explaining how he sometimes seeks atonement through the characters he plays. The actor, 74, spoke at the 2025 Sundance Film Festival in Park City, Utah, on Sunday, Jan. 26, as a ...

  9. These are the top 100 Valentine’s Day gifts, according to Amazon

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    Amazon's annual list of the 100 best Valentine's Day gifts includes options for men, women, and kids.