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Although fluoride is safe for dental health at low concentrations, [1] sustained consumption of large amounts of soluble fluoride salts is dangerous. Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight).
Sodium fluoride (NaF) is an inorganic compound with the formula Na F.It is a colorless or white solid that is readily soluble in water. It is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose.
Fluoride, a naturally occuring mineral found in many foods and water, has been a primary ingredient in toothpaste since the 1970s. Despite being widely regarded as safe by the Food and Drug ...
Fluoride's effects depend on the total daily intake of fluoride from all sources. [51] About 70–90% of ingested fluoride is absorbed into the blood, where it distributes throughout the body. In infants 80–90% of absorbed fluoride is retained, with the rest excreted, mostly via urine; in adults about 60% is retained.
Soluble fluoride salts, of which sodium fluoride is the most common, are toxic, and have resulted in both accidental and self-inflicted deaths from acute poisoning. [4] The lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride per kg body weight).
The principle of fluoride varnish is to apply fluoride salt in a very high concentration (approximately 50,000 ppm) onto the surface of the teeth. [36] Fluoride varnish is a resin-based application that is designed to stay on the surface of the teeth for several hours. As this varnish rests on the tooth's surface, saliva dissolves the fluoride ...
The Department of Health and Human Services said the data was "insufficient" to determine whether the current recommended level of 0.7 milligrams of fluoride per liter of water also had an effect ...
Fluoridated drinking water, fluoride supplements, topical fluoride (fluoride toothpastes), and formula prescribed for children can increase the risk of dental fluorosis. Fluoride is considered an important factor in the management and prevention of dental cavities, the safe level for daily fluoride intake is 0.05 to 0.07 mg/kg/day. [26]