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Work done 12 years later found that the serum phenobarbital 0.111 mg/100 mL for every mg/kg of primidone ingested. Authors publishing a year earlier estimated that 24.5% of primidone was metabolized to phenobarbital, but the patient reported by Kappy and Buckley would have had a serum level of 44.4 mg/100 mL instead of 8.5 mg/100 mL if this ...
Desyrel – an atypical antidepressant used to treat depression and insomnia; Desoxyn (methamphetamine hydrochloride) – used to treat attention deficit hyperactivity disorder and exogenous obesity; Dexedrine (dextroamphetamine sulfate) – used to treat attention deficit hyperactivity disorder and narcolepsy
Phenobarbital causes a depression of the body's systems, mainly the central and peripheral nervous systems. Thus, the main characteristic of phenobarbital overdose is a "slowing" of bodily functions, including decreased consciousness (even coma ), bradycardia , bradypnea , hypothermia , and hypotension (in massive overdoses).
Multiple convenience and random samples, as well as research studies in both clinical and nonclinical sample [22] [1] [23] Internal consistency (Cronbach's alpha, split half, etc.) Good Cronbach's alpha reported at .88 for measuring depression [22] Inter-rater reliability: Good Kappas range from .64-.81 for depression. [24] Kappa for anxiety is ...
Of note, although Mindfulness-based cognitive therapy for depression prevented relapse of future depressive episodes, there is no research on whether it can cause the remission of a current depressive episode. [35] Interpersonal psychotherapy (IPT) focuses on the social and interpersonal triggers that may cause depression. There is evidence ...
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted ().
Ketamine has been tested as a rapid-acting antidepressant [13] for treatment-resistant depression in bipolar disorder, and major depressive disorder. [14] Spravato, a nasal spray form of esketamine, was approved by the FDA in 2019 for use in treatment-resistant depression when combined with an oral antidepressant. [15] [16]
Here are links to possibly useful sources of information about Primidone. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .
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