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Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices".
William Fletcher (born 11 October 1872 in Lemsford, Hertfordshire, [1] died 18 September 1938) [2] was an English medical doctor who in 1907 published the results of an experiment showing beriberi could be prevented by eating unpolished rice. [3] [4]
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TPP is a true catalytic cofactor. In a mechanistic feature common to all its reactions, TPP is a carrier of activated aldehyde moieties. A hydrogen attached to the C2 carbon of the thiazole ring of TPP shows an unusually low pKa. Thiamine deficiency underlies the disorder beriberi.
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In 1946, beriberi was the second leading cause of death in the Philippines, following tuberculosis. [7] In 1948, the survey, led by Dr. Juan Salcedo, Jr. and a team including Dr. M. D. Bamba and three other medical officers, aimed to assess beriberi in the Philippines.