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Neuroplasticity is the process by which neurons adapt to a disturbance over time, and most often occurs in response to repeated exposure to stimuli. [27] Aerobic exercise increases the production of neurotrophic factors [note 1] (e.g., BDNF, IGF-1, VEGF) which mediate improvements in cognitive functions and various forms of memory by promoting blood vessel formation in the brain, adult ...
Endorphins may contribute to the positive effect of exercise on anxiety and depression. [43] The same phenomenon may also play a role in exercise addiction . Regular intense exercise may cause the brain to downregulate the production of endorphins in periods of rest to maintain homeostasis , causing a person to exercise more intensely in order ...
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
The mesolimbic pathway and its positioning in relation to the other dopaminergic pathways. The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine-releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens (NAcc) and olfactory tubercle. [9]
It has an EC 50 Tooltip half-maximal effective concentration for dopamine release of 48.7 nM but induces only 85% release of norepinephrine at a concentration of 10 μM. [16] For comparison, the EC 50 values of the NDRA methcathinone are 49.9 nM for dopamine release and 22.4 nM for norepinephrine release and it induces 100% release of ...
Nootropics (/ n oʊ. ə ˈ t r oʊ p ɪ k s / noh-ə-TROHP-iks or / n oʊ. ə ˈ t r ɒ p ɪ k s / noh-ə-TROP-iks), [1] colloquially brain supplements, smart drugs and cognitive enhancers, are natural, semisynthetic or synthetic compounds which purportedly improve cognitive functions, such as executive functions, attention or memory.