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Newborn infants have low stores of vitamin K, and human breast milk has low concentrations of the vitamin. This combination can lead to vitamin K deficiency and later onset bleeding. Vitamin K deficiency leads to the risk of blood coagulation problems due to impaired production of clotting factors II, VII, IX, X, protein C and protein S by the ...
Vitamin K is a family of structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. [1] The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation ("K" from Danish koagulation, for "coagulation") or for controlling binding of calcium in bones and other tissues. [2]
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Menadione is converted to vitamin K 2 (specifically, MK-4) by the prenyltransferase action of vertebrate UBIAD1. [4] This reaction requires the hydroquinone (reduced) form of K 3, menadiol, produced by NQO1. [6] Menadione is also a circulating form of vitamin K, produced in small amounts (1–5%) after intestinal absorption of K 1 and K 2.
[2] [3] Vitamin K injections are administered to newborns as a preventative measure to reduce the risk of hemorrhagic disease of the newborn (HDN). [ 4 ] [ 5 ] The coagulation pathway helps the body stop active bleeds by using vitamin K dependent clotting factors (factors II, VII, IX, and X) which are synthesized by the liver.
The G.I. Joe: A Real American Hero toyline was introduced by Hasbro in 1982, and lasted to 1994, producing well over 250 vehicles (i.e. in-universe are meant to move under their own power), and playsets (i.e. toys representing static bases of operation such as fortresses, or equipment such as artillery pieces).
Rescue Heroes are a line of action figures targeted towards preschool-age children, released by Fisher-Price.The line was first introduced in 1997, depicting various rescue personnel, such as firefighters, police officers, and construction workers, which included interchangeable tool packs that attached to the back of figures and featured various electronic or mechanical gimmicks.
In January 2007, McFarlane Toys announced plans for a line of 24 action figures. [4] Other series figures have included Lost and The Walking Dead. [30] [31] In 2015, McFarlane toys launched a line of construction sets based on HBO's popular Game of Thrones TV series, [32] followed by a line of 6" action figures to be released in 2019. [33]