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Hemosiderin hyperpigmentation is pigmentation due to deposits of hemosiderin, and occurs in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. [ 1 ] : 853 See also
Hemosiderin image of a kidney viewed under a microscope. The brown areas represent hemosiderin. Hemosiderin or haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron. [1] [2] The body then traps the released iron and stores it as hemosiderin ...
Histopathology of the liver, showing Kupffer cells with significant hemosiderin deposition (shown next to a hepatocyte with lipofuscin pigment, which is a common normal finding). H&E stain. Prussian blue iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or ...
Histopathology of the liver, showing Kupffer cells with significant hemosiderin deposition (shown next to a hepatocyte with lipofuscin pigment, which is a common normal finding). H&E stain. Prussian blue iron staining, highlighting the hemosiderin pigment as blue. This finding indicates mesenchymal iron overload (within Kupffer cells and/or ...
The stain is an important histochemical stain used to demonstrate the distribution and amount of iron deposits in liver tissue, often in the form of a biopsy. [ 6 ] [ 7 ] Perls's procedure may be used to identify excess iron deposits such as hemosiderin deposits ( hemosiderosis ) and in conditions such as hereditary hemochromatosis . [ 8 ]
Superficial siderosis is largely considered a rare disease, with less than 270 total reported cases in scientific literature as of 2006, [2] and affects people of a wide range of ages with men being approximately three times more frequently affected than women. [3]
[5] [8] [14] Later stages show significant hemosiderin deposition in the stroma, fibrosis, and a collapsed appearance of the arterial lumen. [ 8 ] [ 14 ] Clinical differential diagnoses include infantile hemangioma , melanocytic lesions, tufted angioma , insect bite , Kaposi sarcoma , erythema multiforme , and dermatofibroma , depending on the ...
Balanitis plasmacellularis appears as one or more orange-red, glossy, moist, glistening, well-circumscribed, macular to slightly elevated plaque(s). Due to microhemorrhage and hemosiderin deposition, there may be several pinpoint, brighter red spots scattered across the orange-red plaque's backdrop. These spots are referred to as "cayenne ...