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[9] [13] In the United States, it is sold under the brand name Mounjaro for diabetes treatment, [9] and Zepbound for weight loss and treatment of obstructive sleep apnea. [ 10 ] [ 17 ] Tirzepatide is a gastric inhibitory polypeptide analog and GLP-1 receptor agonist . [ 10 ]
Absorption half-life 1 h, elimination half-life 12 h. Biological half-life ( elimination half-life , pharmacological half-life ) is the time taken for concentration of a biological substance (such as a medication ) to decrease from its maximum concentration ( C max ) to half of C max in the blood plasma .
These modifications do not change their broad antibacterial activity, but do affect pharmacological properties such as half-life and binding to proteins in serum. [ 1 ] Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria , chlamydiota ...
The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic. Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing. However, these classifications are based on laboratory behavior.
You may not be familiar with GLP-1 agonists, but there’s a good chance you’ve heard of the brand names attached to this class of drugs: names like Wegovy, Ozempic, Mounjaro, and Zepbound.
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.