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DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A 2 adenosine receptors, in contrast to the A 1 subtype receptors. [1] DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED 50 10 μmol/kg) was similarly higher ...
Cannabis concentrate, also called marijuana concentrate, marijuana extract, or cannabis extract, is a tetrahydrocannabinol (THC) and/or cannabidiol (CBD) concentrated mass. Cannabis concentrates contain high THC levels that range from 40% to over 90%, [ 1 ] [ 2 ] stronger in THC content than high-grade marijuana, which normally measures around ...
THC, the main psychoactive component of cannabis, may only be detectable in saliva and oral fluid for 2–24 hours in most cases. [8] [9] The main metabolite excreted in the urine is 11-Nor-9-carboxy-THC, also known as THC-COOH. Most cannabis drug tests yield a positive result when the concentration of THC-COOH in urine exceeds 50 ng/mL. [10]
They have been designed to be similar to THC, [9] the natural cannabinoid with the strongest binding affinity to the CB 1 receptor, which is linked to the psychoactive effects or "high" of marijuana. [10] These synthetic analogs often have greater binding affinity and greater potency to the CB 1 receptors.
Cannabis was commonly sold in tincture form by Parke-Davis, Eli Lilly, E. R. Squibb & Sons, and other drug manufacturers. [10] [11] By the end of the 19th century, the use of cannabis in medicine had declined due to a number of factors, including difficulty in controlling dosages and the rise in popularity of synthetic and opium-derived drugs. [9]
California’s Business and Professions Code 26011.5 is explicit about the mission of the state cannabis regulatory agency: “The protection of the public shall be the highest priority. …
Following the killing of UnitedHealthcare CEO Brian Thompson and praise for the attack on social media, law enforcement is on high alert as calls for threats against health care executives and ...
Medical marijuana researchers typically prefer to use high-potency marijuana, but NIDA's National Advisory Council on Drug Abuse has been reluctant to provide cannabis with high THC levels, citing safety concerns: [30] Most clinical studies have been conducted using cannabis cigarettes with a potency of 2–4% THC.