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Working together, biologists James Till and Ernest McCulloch made contributions to stem cell research by demonstrating the existence of multipotent stem cells in 1961. They helped lay the foundation for modern stem cell biology and regenerative medicine through their work while studying the effects of radiation on the bone marrow of mice at the Ontario Cancer Institute in Toronto.
Ernest Armstrong McCulloch OC OOnt FRS FRSC [1] (27 April 1926 [2] – 20 January 2011) [3] was a University of Toronto cellular biologist, best known for demonstrating – in a partnership with James Till – the existence of stem cells.
Subsequently, Till chose to work with Ernest McCulloch at the University of Toronto. Thus, the older physician's insight was combined with the younger physicist's rigorous and thorough nature. In the early 1960s, McCulloch and Till started a series of experiments that involved injecting bone marrow cells into irradiated mice. They observed that ...
Research into stem cells grew out of findings by Canadian biologists Ernest McCulloch, James Till and Andrew J. Becker at the University of Toronto and the Ontario Cancer Institute in the 1960s. [ 2 ] [ 3 ] As of 2016 [update] , the only established medical therapy using stem cells is hematopoietic stem cell transplantation , [ 4 ] first ...
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Ernest McCulloch James Till Tak Wah Mak , OC OOnt FRS FRSC ( simplified Chinese : 麦德华 ; traditional Chinese : 麥德華 ; pinyin : Mài Déhuá ; born October 4, 1946, in China ) is a Canadian medical researcher, geneticist, oncologist, and biochemist.
The following is a list of Clarivate Citation candidates considered likely to win the Nobel Prize in Physiology or Medicine. [1] Since 2023, fifteen out of 95 citation laureates starting in 2008 have eventually been awarded a Nobel Prize: Elizabeth Blackburn, Carol W. Greider and Jack W. Szostak (2009), Ralph M. Steinman (posthumously), Bruce Beutler and Jules A. Hoffmann (2011), Shinya ...
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