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This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources .
The diagnosis of Stevens–Johnson syndrome is based on involvement of less than 10% of the skin. [2] It is known as TEN when more than 30% of the skin is involved and considered an intermediate form when 10–30% is involved. [3] SJS/TEN reactions are believed to follow a type IV hypersensitivity mechanism. [7]
Terbinafine is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot. [1] [2] [3] It is either taken by mouth or applied to the skin as a cream or ointment.
The hypersensitivity syndrome is characterized by a rash that is initially rash that appears similar to measles (morbilliform). [2]: 118 The rash may also be one of the potentially lethal severe cutaneous adverse reactions, the DRESS syndrome, Stevens–Johnson syndrome, or toxic epidermal necrolysis.
NSAIDs are also implicated in some cases of Stevens–Johnson syndrome. [106] Most NSAIDs penetrate poorly into the central nervous system (CNS). However, the COX enzymes are expressed constitutively in some areas of the CNS, meaning that even limited penetration may cause adverse effects such as somnolence and dizziness. [107]
Stevens-Johnson/toxic epidermal necrolysis overlap syndrome (SJS/TEN); and Acute generalized exanthematous pustulosis (AGEP). The five disorders have similar pathophysiologies , i.e. disease-causing mechanisms, for which new strategies are in use or development to identify individuals predisposed to develop the SCARs-inducing effects of ...
Hepatotoxicity and Stevens–Johnson Syndrome [3] Chlorphentermine: 1969 Germany Cardiovascular Toxicity. [3] Cianidanol: 1985 France, Germany, Spain, Sweden Hemolytic Anemia. [3] Cinepazide: 1988 Spain Agranulocytosis. [12] [13] Cisapride (Propulsid) 2000 US Risk of fatal cardiac arrhythmias [2] Clioquinol: 1973 France, Germany, UK, US ...
The oral suspension form produces a number of adverse effects including but not limited to: [13] Diarrhea; Abdominal pain; Rarely, tachycardia, bronchospasm, facial swelling, muscle aches; Both the oral suspension and the topical form can cause: Hypersensitivity reactions, including Stevens–Johnson syndrome in some cases [14]