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Histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. [ 5 ] [ 6 ] It is an important part of anatomical pathology and surgical pathology , as accurate diagnosis of cancer and other diseases often requires histopathological examination of tissue samples. [ 10 ]
Immunohistochemistry can be performed on tissue that has been fixed and embedded in paraffin, but also cryopreservated (frozen) tissue.Based on the way the tissue is preserved, there are different steps to prepare the tissue for immunohistochemistry, but the general method includes proper fixation, antigen retrieval incubation with primary antibody, then incubation with secondary antibody.
The second method of histology processing is called frozen section processing. This is a highly technical scientific method performed by a trained histoscientist. In this method, the tissue is frozen and sliced thinly using a microtome mounted in a below-freezing refrigeration device called the cryostat. The thin frozen sections are mounted on ...
In histology, a clear cell is a cell that shows a clear cytoplasm when stained with hematoxylin and eosin (H&E). [1] Normal histology.
In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function. [1] [2] Tissues occupy a biological organizational level between cells and a complete organ.
The H&E staining procedure is the principal stain in histology [3] [7] [2] [5] in part because it can be done quickly, [7] is not expensive, and stains tissues in such a way that a considerable amount of microscopic anatomy [9] [10] is revealed, [7] [5] [4] and can be used to diagnose a wide range of histopathologic conditions. [8]
Koilocytosis or koilocytic atypia or koilocytotic atypia are terms used in histology and cytology to describe the presence of koilocytes in a specimen. [1] Koilocytes may have the following cellular changes: Nuclear enlargement (two to three times normal size). Irregularity of the nuclear membrane contour, creating a wrinkled or raisinoid ...
[1] [2] The counterpart to gross anatomy is the field of histology, which studies microscopic anatomy. [ 1 ] [ 2 ] Gross anatomy of the human body or other animals seeks to understand the relationship between components of an organism in order to gain a greater appreciation of the roles of those components and their relationships in maintaining ...