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The primary endpoint might be a statistically significant improvement in overall survival (OS). A trial might also define one or more secondary endpoints such as progression-free-survival (PFS) that will be measured and are expected to be met. A trial might also define exploratory endpoints that are less likely to be met.
Thesaurus Linguae Latinae. A modern english thesaurus. A thesaurus (pl.: thesauri or thesauruses), sometimes called a synonym dictionary or dictionary of synonyms, is a reference work which arranges words by their meanings (or in simpler terms, a book where one can find different words with similar meanings to other words), [1] [2] sometimes as a hierarchy of broader and narrower terms ...
Endpoint (chemistry), the conclusion of a chemical reaction, particularly for titration Outcome measure , a measure used as an endpoint in research Clinical endpoint , in clinical research, a disease, symptom, or sign that constitutes one of the target outcomes of the trial or its participants
A surrogate endpoint of a clinical trial is a laboratory measurement or a physical sign used as a substitute for a clinically meaningful endpoint that measures directly how a patient feels, functions or survives. Changes induced by a therapy on a surrogate endpoint are expected to reflect changes in a clinically meaningful endpoint. [8]
An end point assay, in which a single measurement is performed after a fixed incubation period; or A kinetic assay , in which measurements are performed multiple times over a fixed time interval. Kinetic assay results may be visualized numerically (for example, as a slope parameter representing the rate of signal change over time), or ...
A thesaurus or synonym dictionary lists similar or related words; these are often, but not always, synonyms. [15] The word poecilonym is a rare synonym of the word synonym. It is not entered in most major dictionaries and is a curiosity or piece of trivia for being an autological word because of its meta quality as a synonym of synonym.
Major adverse cardiovascular events (MACE, or major adverse cardiac events) is a composite endpoint frequently used in cardiovascular research. [1] [2] Despite widespread use of the term in clinical trials, the definitions of MACE can differ, which makes comparison of similar studies difficult. [3]
A vertex of an angle is the endpoint where two lines or rays come together. In geometry, a vertex (pl.: vertices or vertexes) is a point where two or more curves, lines, or edges meet or intersect. As a consequence of this definition, the point where two lines meet to form an angle and the corners of polygons and polyhedra are vertices. [1] [2] [3]