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On 30 March 1842, he administered diethyl ether by inhalation to a man named James Venable, in order to remove a tumor from the man's neck. [102] Long later removed a second tumor from Venable, again under ether anesthesia. He went on to employ ether as a general anesthetic for limb amputations and childbirth. Long, however, did not publish his ...
[2] It was a mixture of alcohol, chloroform and ether [1] [3] which gives the mixture its name. Its effects were said to be between that of chloroform and ether and it was used when ether alone was contraindicated. [1] Its boiling point was given as 48°C. [4] Its actual safety margin over its components alone was marginal. [5] [6]
[1] [2] If tape is used to hold the eyes closed, ocular injury occurs during 0.1-0.5% of general anaesthetics, and is usually corneal in nature. [3] [4] Intraoperative eye injuries account for 2% of medico-legal claims against anaesthetists in Australia and United Kingdom, [3] [1] and 3% in the USA. [5]
Since 1982, ether is not used in the United States. [7] Now, because of the use of intravenous induction agents with muscle relaxants and the discontinuation of ether, elements of Guedel's classification have been superseded by depth of anaesthesia monitoring devices such as the BIS monitor; [5] however, the use of BIS monitoring remains ...
The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
Historically, ether (the first volatile agent) was first used by John Snow's inhaler (1847) but was superseded by the use of chloroform (1848). Ether then slowly made a revival (1862–1872) with regular use via Curt Schimmelbusch's "mask", a narcosis mask for dripping liquid ether. Now obsolete, it was a mask constructed of wire, and covered ...
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