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These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low-frequency GnRH pulses are required for FSH release, whereas high-frequency GnRH pulses stimulate LH pulses in a one-to-one manner. [10] There are differences in GnRH secretion between females and males.
The frequency and amplitude of GnRH pulses are tightly regulated, particularly in women, over the course of the reproductive cycle. For instance, the FSHβ gene exhibits ultrasensitive behavior in response to GnRH pulse frequency, with its expression sharply increasing at lower pulse frequencies and decreasing at higher frequencies.
The strongest activator of GnRH neurons is a hormone called kisspeptin. [16] GnRH neurons also integrate information from the body through hormones like neuropeptide Y [17] and adiponectin. [18] These hormones provide the GnRH neurons with information about the body's status to help determine whether reproduction should be prioritized or ...
LH is released from the pituitary gland along with FSH in response to GnRH release into the hypophyseal portal system. [4] Pulsatile GnRH release causes pulsatile LH and FSH release to occur, which modulates and maintains appropriate levels of bioavailable gonadal hormone—testosterone in males and estradiol in females—subject to the requirements of a superior feedback loop. [3]
It's no secret that Women usually live longer than men. The question is how do they do it? Well now, Stanford University scientists may have some answers, EyeOpener explains.
Kisspeptin then activates the GPR54 receptors on GnRH neurons inducing the pulsatile release of GnRH and on KNDy neurons, adding to the stimulatory effect of NKB. [2] Eventually the pulse is terminated by dynorphin, which acts on κ-opioid receptors (KOR) in KNDy neurons to inhibit NKB and kisspeptin secretion and inhibits GnRH secretion acting ...
Frequency: 1:30,000 (males), 1:125,000 (females) ... is reduced to a very low level of GnRH release in adult life with no obvious cause (e.g. a pituitary tumour ...
Life expectancy in the U.S. is currently 77.5 years for men and women, although plenty of people live much longer than that. Now, new research is breaking down the common traits of people who live ...