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Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. [ 1 ] In neurodegenerative diseases , cells of the central nervous system stop working or die via neurodegeneration .
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [14] It is the most common neurodegenerative disease. [1]
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Encephalopathy (/ ɛ n ˌ s ɛ f ə ˈ l ɒ p ə θ i /; from Ancient Greek ἐγκέφαλος (enképhalos) 'brain' and πάθος (páthos) 'suffering') means any disorder or disease of the brain, especially chronic degenerative conditions. [1]
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Degeneration is deterioration in the medical sense. Generally, it is the change from a higher to a lower form. More specifically, it is the change of tissue to a lower or less functionally active form. True degeneration: when there is actual chemical change of the tissue itself.
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5] [6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7] The most common symptoms are joint pain and stiffness. [1]
A neuromuscular disease is any disease affecting the peripheral nervous system (PNS), [a] the neuromuscular junctions, or skeletal muscles, all of which are components of the motor unit. [4] Damage to any of these structures can cause muscle atrophy and weakness. Issues with sensation can also occur. Neuromuscular diseases can be acquired or ...