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Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only the ...
The name rhesus factor (Rh) goes back to the use of erythrocytes extracted from the blood of rhesus monkeys for obtaining the first blood serum. The Rh blood group system is a human blood group system. It contains proteins on the surface of red blood cells. After the ABO blood group system, it is most likely to be involved in transfusion reactions.
The entire Rh blood group system involves multiple antigens and genes. For Rh factor testing, however, only the Rhesus factor correlated to the RhD antigen is assayed. The RhD gene that codes for the RhD antigen is located on chromosome 1. This chromosome contains gene instructions for making proteins in the body. [3]
Rh deficiency syndrome is a type of hemolytic anemia that involves erythrocytes whom membranes are deficient in Rh antigens. It is considered a rare condition. [56] Sickle-cell disease: Sickle cell disease is a group of inherited blood disorders, caused by a genetic abnormality in the oxygen-carrying protein haemoglobin found in red blood cells ...
Hemolytic disease of the newborn (HDN) Rh disease (Rh D) ABO hemolytic disease of the newborn; Anti-Kell hemolytic disease of the newborn; Rhesus c hemolytic disease of the newborn; Rhesus E hemolytic disease of the newborn; Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others) Drug induced immune mediated hemolytic anemia
Younger age, female, immunocompromised, or existing renal, urinary, or lower GI disease (because these are the systems involved in the disease) [1] Diagnostic method: Blood tests (to monitor levels of platelets, red blood cells, and white blood cells), stool tests (especially to check for microscopic or macroscopic levels of fresh or old blood ...
Rh o (D) immune globulin (RhIG) is a medication used to prevent RhD isoimmunization in mothers who are RhD negative and to treat idiopathic thrombocytopenic purpura (ITP) in people who are Rh positive. [2] It is often given both during and following pregnancy. [2] It may also be used when RhD-negative people are given RhD-positive blood. [2]
Vos originally described Rh-deficiency syndrome in 1961, when a sample of blood failed to respond with several Rh antisera. However, R. Ceppellini used the term "Rhnull" for the first time. So far, at least 43 people from 14 families have been reported in the literature as having the Rhnull phenotype. [4]