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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck ( IC 50 =4 nM ), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM).
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The full extent of the payment became clear only twelve years later, in 1993, during the mani pulite (Italian for "clean hands") investigations into political corruption. The money was allegedly a kickback on a loan which the Socialist leaders had organised to help bail out the ailing Banco Ambrosiano .
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Perfluoromethylcyclohexane is chemically inert and thermally stable (to over 400 °C). It is non-toxic. [2]It is a clear, colorless liquid, with a relatively high density, low viscosity and low surface tension that will rapidly evaporate.