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The term "leukoaraiosis" was coined in 1986 [6] [7] by Hachinski, Potter, and Merskey as a descriptive term for rarefaction ("araiosis") of the white matter, showing up as decreased density on CT and increased signal intensity on T2/FLAIR sequences (white matter hyperintensities) performed as part of MRI brain scans. These white matter changes ...
In September 2021, two studies [30] found white matter alterations in parts of the visual cortex and outside the visual cortex in patients with visual snow syndrome. In November 2023, a study [ 31 ] revealed that glutamate and serotonin are involved in brain connectivity alterations in areas of the visual, salience, and limbic systems in VSS.
Scintillating scotomas are most commonly caused by cortical spreading depression, a pattern of changes in the behavior of nerves in the brain during a migraine. Migraines, in turn, may be caused by genetic influences and hormones. People with migraines often self-report triggers for migraines involving stress or foods, [9] or bright lights. [10]
These small regions of high intensity are observed on T2 weighted MRI images (typically created using 3D FLAIR) within cerebral white matter (white matter lesions, white matter hyperintensities or WMH) [1] [2] or subcortical gray matter (gray matter hyperintensities or GMH). The volume and frequency is strongly associated with increasing age. [2]
An MRI of the brain showed minor white-matter abnormalities near the lentiform nucleus and in the semioval center. The visual perceptions she had experienced were attributed to unusual electrophysiological activity in the regions of the brain that are specialised for face and colour in the ventral occipito-temporal cortex.
Photopsia is the presence of perceived flashes of light in the field of vision. It is most commonly associated with: [4] posterior vitreous detachment; migraine aura (ocular migraine / retinal migraine) migraine aura without headache; scintillating scotoma; retinal break or detachment; occipital lobe infarction (similar to occipital stroke)
The MRI of patients with VWM shows a well defined leukodystrophy. These MRIs display reversal of signal intensity of the white matter in the brain. Recovery sequences and holes in the white matter are also visible. [4] Over time, the MRI is excellent at showing rarefaction and cystic degeneration of the white matter as it is replaced by fluid.
T2 weighted axial scan of a human brain at the level of the caudate heads demonstrates marked loss of posterior white matter, with reduced volume and increased signal intensity. The anterior white matter is spared. Features are consistent with X-linked adrenoleukodystrophy. Specialty: Neurology
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