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A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule. The name of the precursor for a protein is often prefixed by pro-.
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [ 5 ] and has been implicated as a regulator of synapse formation , [ 6 ] neural plasticity , [ 7 ] antimicrobial activity, [ 8 ] and iron export . [ 9 ]
333 11803 Ensembl ENSG00000105290 ENSMUSG00000006651 UniProt P51693 Q03157 RefSeq (mRNA) NM_005166 NM_001024807 NM_007467 RefSeq (protein) NP_001019978 NP_005157 NP_031493 Location (UCSC) Chr 19: 35.87 – 35.88 Mb Chr 7: 30.13 – 30.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in ...
Significant efforts have been focused on the mechanisms responsible for Aβ production, including the proteolytic enzymes gamma- and β-secretases which generate Aβ from its precursor protein, APP (amyloid precursor protein). [36] [37] Aβ circulates in plasma, cerebrospinal fluid (CSF) and brain interstitial fluid (ISF) mainly as soluble Aβ40.
APLP2 is part of a family of mammalian membrane proteins along with APLP1 and amyloid precursor protein (APP). [18] Since APP plays a key role in the molecular pathology of Alzheimer’s disease (AD), it has been hypothesized that APLP2 also plays a role in AD pathogenesis. [19]
Prosaposin, also known as PSAP, is a protein which in humans is encoded by the PSAP gene. [5]This highly conserved glycoprotein is a precursor for 4 cleavage products: saposins A, B, C, and D. Saposin is an acronym for Sphingolipid Activator PrO[S]teINs. [6]
BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. Presenilin is believed to harbor the protease domain and represents an important example of an uncommon type of protease that cleaves targets within the cell membrane.
Pages in category "Precursor proteins" The following 32 pages are in this category, out of 32 total. This list may not reflect recent changes. ...