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A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by post-translational modification, such as breaking off a piece of the molecule or adding on another molecule. The name of the precursor for a protein is often prefixed by pro-.
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [ 5 ] and has been implicated as a regulator of synapse formation , [ 6 ] neural plasticity , [ 7 ] antimicrobial activity, [ 8 ] and iron export . [ 9 ]
333 11803 Ensembl ENSG00000105290 ENSMUSG00000006651 UniProt P51693 Q03157 RefSeq (mRNA) NM_005166 NM_001024807 NM_007467 RefSeq (protein) NP_001019978 NP_005157 NP_031493 Location (UCSC) Chr 19: 35.87 – 35.88 Mb Chr 7: 30.13 – 30.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in ...
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients.
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein.
APLP2 is part of a family of mammalian membrane proteins along with APLP1 and amyloid precursor protein (APP). [18] Since APP plays a key role in the molecular pathology of Alzheimer’s disease (AD), it has been hypothesized that APLP2 also plays a role in AD pathogenesis. [19]
Prosaposin, also known as PSAP, is a protein which in humans is encoded by the PSAP gene. [5]This highly conserved glycoprotein is a precursor for 4 cleavage products: saposins A, B, C, and D. Saposin is an acronym for Sphingolipid Activator PrO[S]teINs. [6]
BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. Presenilin is believed to harbor the protease domain and represents an important example of an uncommon type of protease that cleaves targets within the cell membrane.