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Plays a role in immune defense against viruses: IL-29-Plays a role in host defenses against microbes: IL-30-Forms one chain of IL-27: IL-31: Th2 cells: IL31RA: May play a role in inflammation of the skin: IL-32-Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2: IL-33: epithelial cells: Induces helper T cells to produce type 2 ...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system.It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.
3553 16176 Ensembl ENSG00000125538 ENSMUSG00000027398 UniProt P01584 P10749 RefSeq (mRNA) NM_000576 NM_008361 RefSeq (protein) NP_000567 NP_032387 Location (UCSC) Chr 2: 112.83 – 112.84 Mb Chr 2: 129.21 – 129.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor ...
Interleukin-13 has a critical role in goblet cell metaplasia. [12] Goblet cells are filled with mucin (MUC). [12] MUC5AC Mucin 5AC is a gel-like mucin product of goblet cells. [12] Interleukin-13 induces goblet cell differentiation and allows for the production of MUC5AC in tracheal epithelium.
3586 16153 Ensembl ENSG00000136634 ENSMUSG00000016529 UniProt P22301 P18893 RefSeq (mRNA) NM_000572 NM_010548 RefSeq (protein) NP_000563 NP_034678 Location (UCSC) Chr 1: 206.77 – 206.77 Mb Chr 1: 130.95 – 130.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti- inflammatory cytokine ...
IL-18 in combination with IL12 acts on CD4, CD8 T cells and NK cells to induce IFNγ production, type II interferon that plays an important role in activating the macrophages or other cells. The combination of IL-18 and IL-12 has been shown to inhibit IL-4 dependent IgE and IgG1 production and enhance IgG2a production in B cells . [ 17 ]
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. [2] They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23.