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  2. Tricyclic antidepressant overdose - Wikipedia

    en.wikipedia.org/wiki/Tricyclic_antidepressant...

    Tricyclics have a narrow therapeutic index, i.e., the therapeutic dose is close to the toxic dose. [7] Factors that increase the risk of toxicity include advancing age, cardiac status, and concomitant use of other drugs. [8] However, serum drug levels are not useful for evaluating risk of arrhythmia or seizure in tricyclic overdose. [9]

  3. Metals in medicine - Wikipedia

    en.wikipedia.org/wiki/Metals_in_medicine

    Toxic metal poisoning is usually treated with some type of chelating agent. [2] [3] Heavy metal poisoning, such as from mercury, cadmium, or lead, is particularly pernicious. Examples of specific types of toxic metals include: Copper: copper toxicity usually presents itself as a side effect of low levels of the protein ceruloplasmin, which ...

  4. Metal toxicity - Wikipedia

    en.wikipedia.org/wiki/Metal_toxicity

    Many metals, particularly heavy metals are toxic, but some are essential, and some, such as bismuth, have a low toxicity. Metals in an oxidation state abnormal to the body may also become toxic: chromium(III) is an essential trace element, but chromium(VI) is a carcinogen. Only soluble metal-containing compounds are toxic. Soluble metals are ...

  5. Toxic encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Toxic_encephalopathy

    Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...

  6. Lithium toxicity - Wikipedia

    en.wikipedia.org/wiki/Lithium_toxicity

    Lithium toxicity, also known as lithium overdose, is the condition of having too much lithium. Symptoms may include a tremor, increased reflexes, trouble walking, kidney problems, and an altered level of consciousness. Some symptoms may last for a year after levels return to normal. Complications may include serotonin syndrome. [1]

  7. Pharmacotoxicology - Wikipedia

    en.wikipedia.org/wiki/Pharmacotoxicology

    In this case, both the therapeutic and toxic targets are the same. To avoid toxicity during treatment, many times the drug needs to be changed to target a different aspect of the illness or symptoms. Statins are an example of a drug class that can have toxic effects at the therapeutic target (HMG CoA reductase). [1]

  8. Bromism - Wikipedia

    en.wikipedia.org/wiki/Bromism

    High levels of bromide chronically impair the membrane of neurons, which progressively impairs neuronal transmission, leading to toxicity, known as bromism. Bromide has an elimination half-life of 9 to 12 days, which can lead to excessive accumulation. Doses of 0.5 to 1 gram per day of bromide can lead to bromism.

  9. Benzodiazepine overdose - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_overdose

    The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2]

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