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[4] [6] AG is a second- or third-line choice in the treatment of hormone-sensitive metastatic breast cancer. While effective in the treatment of breast cancer in postmenopausal women, it is not effective in premenopausal women and is not an effective ovarian steroidogenesis inhibitor, probably because it is not a potent enough aromatase inhibitor.
1,4,6-Androstatriene-3,17-dione (ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. [1] It is used to control estrogen synthesis. [2]
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, [1] [2] and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.
[4] [5] [6] Aromatase is responsible for the conversion of testosterone to estradiol. Blocking aromatase causes the body to decrease in levels of estradiol, which then results in increase of LH and consequently, testosterone. Since testosterone has myotropic activity and estradiol does not, elevated testosterone levels increase muscle mass.
Known in the field of prohormones Patrick Arnold (the one who introduced 1-AD and the first prohormones) is currently working on ursolic acid, on the other hand in Eastern Europe manufacturers launch supplements based on buteins, [11] - natural compounds considered as the strongest aromatase inhibitors.
This treatment uses synthetic testosterone to increase circulating testosterone levels and reduce low T symptoms. TRT comes in several forms, including skin patches, topical gels, oral capsules ...
5 Benefits of DHEA Supplements for Men, From Depression Treatment to Increased Testosterone. One peek down a drugstore aisle and you’ll probably notice DHEA supplements.
Aromatase in fat and muscle can circulate estrogen in postmenopausal women. [12] Aromatase in highly estrogen-sensitive tissues, such as the breast, uterus, vagina, bone, and blood vessels, provides estrogen locally, so aromatase inhibitors work by reducing this estrogen production. [12]
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