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Ringer's lactate solution is in the crystalloid family of medications. [5] It is isotonic, i.e. it has the same tonicity as blood. [2] Ringer's solution was invented in the 1880s; lactate was added in the 1930s. [4] It is on the World Health Organization's List of Essential Medicines. [6] Lactated Ringer's is available as a generic medication. [1]
Lactated Ringer's solution contains 28 mmol/L lactate, 4 mmol/L K + and 1.5 mmol/L Ca 2+. It is very similar – though not identical – to Hartmann's solution , the ionic concentrations of which differ slightly.
Ringer's solution is a solution of several salts dissolved in water for the purpose of creating an isotonic solution relative to the body fluids of an animal. Ringer's solution typically contains sodium chloride , potassium chloride , calcium chloride and sodium bicarbonate , with the last used to buffer the pH .
It was at this time that medical providers began to use amnioinfusion for other therapeutic purposes. [15] The first report of using isotonic saline or Lactated Ringers solution for repeated late decelerations on fetal heart tracing was in 1983 using either a spinal needle or transcervical catheter. [15]
Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as maize or beets , and then, by neutralizing the resulting lactic acid [ 4 ] to create a compound having the formula NaC 3 H 5 O 3 .
The management of an acute event of vaso-occlusive crisis is the use of potent analgesics , [5] rehydration with normal saline or Ringer's lactate, treatment of malaria (whether symptomatic or not) using artemisinin combination therapy, and the use of oxygen via face mask, especially for acute chest syndrome.
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[1] [2] [3] The milliliter amount of fluid required for the first 24 hours – usually Lactated Ringer's – is four times the product of the body weight and the burn percentage (i.e. body surface area affected by burns). [4] The first half of the fluid is given within eight hours from the burn incident, and the remaining over the next 16 hours.