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Tetracycline, sold under various brand names, is an antibiotic in the tetracyclines family of medications, used to treat a number of infections, [3] ...
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.
The overall structure of TetR can be broken down into two DNA-binding domains (one per monomer) and a regulatory core, which is responsible for tetracycline recognition and dimerization. TetR dimerizes by making hydrophobic contacts within the regulatory core. There is a binding cavity for tetracycline in the outer helices of the regulatory domain.
Tetracycline-controlled transcriptional activation is a method of inducible gene expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (e.g. doxycycline).
Minocycline is a tetracycline derivative. [28] [64] It is closely structurally related to other tetracyclic antibiotics such as tetracycline, doxycycline, and tigecycline. [64] [28] The drug is used in form of minocycline hydrochloride dihydrate, [69] which is sparingly soluble in water and slightly soluble in ethanol. Minocycline reacts acidic ...
Mildly infuriating that I have to go back outside in the cold to get a new box, I was so ready to unwind from work too. Image credits: Responsible_Wafer208 #52 Crazy. Image credits: ellenfromnowon
Doxycycline is a broad-spectrum antibiotic of the tetracycline class used in the treatment of infections caused by bacteria and certain parasites. [1] It is used to treat bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis. [1]
Tetracycline (minocycline, doxycycline) Macrolide (erythromycin, azithromycin) Topical Clindamycin. Topical Erythromycin. Hazal Ak/istockphoto. Non-Antibiotic Oral Medications.