Search results
Results From The WOW.Com Content Network
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
Approximately 60% of FVB Mice regardless of sex survive to two years of age. [6] By this point, approximately 60% of surviving mice show tumors/lesions. Some sudden deaths are observed in younger animals, but most die at 15 months or older. Two years is a common life expectancy in wild-type house mice.
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Some laboratory mouse strains, such as C57BL/6, are domesticated from M. m. domesticus. [1] Distribution
This black coloured mouse is a sub-strain of C57BL/6 created in 1921 by C. C. Little at the Bussey Institute for Research in Applied Biology. It is used widely in genetics, toxicology and as pet. [20] The majority of the genome is from M. m. domesticus, while smaller portion is of M. m. molossinus. [21]
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
The confounding presence of neighbouring 129 genes on the knockout segment of genetic material has been dubbed the "flanking-gene effect". [6] Methods and guidelines to deal with this problem have been proposed. [7] [8] Another limitation is that conventional (i.e. non-conditional) knockout mice develop in the absence of the gene being ...